Preventive Maintenance Plans for a Closed Loop Lab
Daily, weekly, monthly and quarterly maintenance checklists for recovery pumps, chillers, vacuum pumps and ovens, seals, filters, sensors and hoses.
Most downtime I've seen in extraction labs traces back to small things nobody checked: a tired gasket, a clogged filter, a sensor out of calibration. A written preventive maintenance (PM) plan turns those into routine tasks instead of emergencies.
Build the plan around your equipment list
Start with an asset register: every piece of sub-equipment, its serial number, manufacturer manual, service intervals and who owns it. Then turn manufacturer intervals into a calendar. Where a manual is stricter than this page, the manual wins.
Example PM checklist
| Equipment | Daily | Weekly | Monthly | Quarterly |
|---|---|---|---|---|
| Recovery pumps | Visual check for leaks, unusual noise, logged run hours | Inspect inlet filters/strainers | Check fittings and mounts; review run-hour trend | Service per manufacturer (seals/rebuild kit as scheduled) |
| Chillers | Confirm setpoint reached and alarms clear | Check fluid level and condition | Clean condenser coils/filters | Fluid replacement and full service per manual |
| Vacuum pumps & ovens | Confirm gauges read normally; log any drift | Check oil level/condition (oil pumps) | Oil change per hours used; inspect door gaskets | Calibrate gauges and temperature controllers |
| Seals & gaskets | Inspect any seal opened that day | Spot-check clamp connections | Replace worn or deformed gaskets from stock | Full seal audit across the system |
| Filters & media | Replace single-use filters per SOP | Check housings for damage | Review filter usage vs production | Audit filter spec and supplier |
| Sensors & gas detection | Confirm detectors powered and alarm-free | Bump test per manufacturer | Review alarm logs | Calibration by qualified provider |
| Hoses & lines | Look for kinks, abrasion, discoloration | Check fitting tightness and labels | Inspect against rated life/date codes | Replace on schedule or when in doubt |
Example intervals only. Use your manufacturer's and engineer's schedule.
Fix in house when you can
Many failures on chillers, recovery pumps and compressors, heaters and water pumps are mechanical and diagnosable on site. I diagnose and repair most of these issues in house, and call the manufacturer or a licensed technician when a repair needs certification (for example refrigerant work) or is under warranty.
Keep records an inspector can follow
Every PM task should leave a trace: date, initials, what was found, parts used. A simple logbook or CMMS works as long as it is consistent. Tie repairs to work orders, and track parts used so your spare-parts stock stays honest.
Spare parts that save the day
- Gaskets and seals in every size you run
- Filters and filter media
- Pump rebuild kits and vacuum pump oil
- Spare sensors or a loaner plan with your calibration vendor
- Common fittings and clamps
Questions
How often should a closed loop system be maintained?
Follow the manufacturer and engineer schedule, then add daily visual checks and logged weekly, monthly and quarterly tasks. High-volume labs often need tighter intervals.
What fails most often?
In my experience: seals and gaskets, filters, and pumps that miss scheduled service. Those are cheap to stock and easy to schedule.
Want a second set of eyes?
I run workflow audits and GMP mock audits for licensed labs.
Ready when you areGet a closed loop expert in your lab
Setup, repairs, upgrades, diamond programs or a GMP mock audit. I travel and live on site at licensed facilities.